Sarcoidosis atípica en un joven con úlceras cutáneas e hipercalcemia
Palabras clave:
sarcoidosis, hipercalcemia, úlcera cutánea
Resumen
La sarcoidosis es una enfermedad inflamatoria sistémica idiopática que afecta principalmente a los pulmones. Las manifestaciones extrapulmonares ocurren aproximadamente en 30% de los pacientes. Los sitios más comunes de enfermedad extrapulmonar incluyen la piel, los globos oculares, el sistema reticuloendotelial, el sistema musculoesquelético, las glándulas exócrinas, el corazón, los riñones y el sistema nervioso central. Presentamos un caso clínico de sarcoidosis con afectación de ganglios linfáticos periféricos, alteración renal y cutánea sin afectación pulmonar el cual representa un desafío diagnóstico por la ausencia de las características típicas de esta patología.
Citas
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2. King TE Jr. Extrapulmonary manifestations of sarcoidosis. Uptodate /Internet/. 2018 /cited 2 dic 2018/. Available from: https://www.uptodate.com/contents/extrapulmonary-manifestations-of-sarcoidosis.
3. Katta N, Gautam S, Littrell R. Sarcoidosis presenting as complete heart block in a young morbidly obese patient with severe obstructive sleep apnea and on beta blocker. JAAC. 2017; 69(11): Poster 2335.
4. Fontenot A, King TE Jr. Pathology and pathogenesis of sarcoidosis. Uptodate /Internet/. 2018 /cited 30 nov 2018/. Available from: https://www.uptodate.com/contents/pathology-and-pathogenesis-of-sarcoidosis.
5. Powe NR, Peterson PG, Mark EJ. Case records of the Massachusetts general hospital. Case 27-2015 — A 78-year-old man with hypercalcemia and renal failure. N Engl J Med. 2015; 373(9): 864-73.
6. King TE Jr. Treatment of pulmonary sarcoidosis: Initial therapy with glucocorticoids. Uptodate /Internet/. 2018 /cited 28 nov 2018/. Available from: https://www.uptodate.com/contents/treatment-of-pulmonary-sarcoidosis-initial-therapy-with-glucocorticoids.
7. Fernández Fabrellas E. Epidemiología de la sarcoidosis. Arch Bronconeumol. 2007; 43(2):92-100.
8. Braun JJ, Gentine PG. Sinonasal sarcoidosis: Review and report of fifteen cases. Laryngoscope. 2004; 114(11):1960-3.
9. annuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med. 2007; 357(21):2153-65.
10. Karunakara BP, Maiya PP, Mallikarjuna HB. Childhood sacoidosis presenting as recurrent erythema nodosum. Indian J Pediatr. 2002; 69(9): 829.
11. Zapata González F, Vásquez Ochoa LA, Arroyave Sierra JE, Arredondo Ossa MI, Molina Vélez V, Del Río Cobaleda DY. Sarcoidosis cutánea. CES Med. 2014; 28(2): 293-306.
12. Prystowsky S, Sanchez M. Cutaneous manifestations of sarcoidosis. Uptodate [Internet]. 2019 [cited 2019 Febr 2]. Available from: https://www.uptodate.com/contents/cutaneous-manifestations-of-sarcoidosis?search=sarcoidosis%20cutanea&source=search_result&selectedTitle=1~47&usage_type=default&display_rank=1.
13. Galeano AP, Vecchio E, Calzinari C, Velázquez C, Dilzician V, Guglielmone A, et al. Sarcoidosis cutánea. Rev. argent. dermatol [Internet]. 2013 [cited 2019 febr 2]; 94(4): 22-4. Available from: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-300X2013000400007.
14. Shane E. Diagnostic approach to hypercalcemia. Uptodate [Internet]. 2018 [cited 2019 Febr 1]. Available from: https://www.uptodate.com/contents/diagnostic-approach-to-hypercalcemia?search=hipercalcemia&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1#H3446399644.
15. Baughman RP, Teirstein AS, Judson MA, Rossman MD, Yeager H Jr, Bresnitz EA, et al. Clinical characteristics of patients in a case control study of sarcoidosisl. Am J Respir Crit Care Med. 2001;164(10 Pt 1):1885-9.
16. Villanueva Gimeno MM, Kurnat Y, Vázquez Rodríguez J, Gracia Sánchez MP, Galindo Esteban MC. Síndrome de Löfgren. A propósito de un caso. SEMERGEN. 2009; 35(5):249-51.
17. Mañá J. Diagnóstico y tratamiento de la patología de la sarcoidosis. Barcelona : Servicio de Medicina Interna. Hospital Universitari de Bellvitge. IDIBELL. L’Hospitalet de Llobregat; 2009.
18. Prystowsky S, Sanchez M. Management of cutaneous sarcoidosis. Uptodate [Internet]. 2017 [cited 2019 Enero 30]. Available from: https://www.uptodate.com/contents/management-of-cutaneous-sarcoidosis?search=sarcoidosis%20cutanea&source=search_result&selectedTitle=2~47&usage_type=default&display_rank=2#H324690.
2. King TE Jr. Extrapulmonary manifestations of sarcoidosis. Uptodate /Internet/. 2018 /cited 2 dic 2018/. Available from: https://www.uptodate.com/contents/extrapulmonary-manifestations-of-sarcoidosis.
3. Katta N, Gautam S, Littrell R. Sarcoidosis presenting as complete heart block in a young morbidly obese patient with severe obstructive sleep apnea and on beta blocker. JAAC. 2017; 69(11): Poster 2335.
4. Fontenot A, King TE Jr. Pathology and pathogenesis of sarcoidosis. Uptodate /Internet/. 2018 /cited 30 nov 2018/. Available from: https://www.uptodate.com/contents/pathology-and-pathogenesis-of-sarcoidosis.
5. Powe NR, Peterson PG, Mark EJ. Case records of the Massachusetts general hospital. Case 27-2015 — A 78-year-old man with hypercalcemia and renal failure. N Engl J Med. 2015; 373(9): 864-73.
6. King TE Jr. Treatment of pulmonary sarcoidosis: Initial therapy with glucocorticoids. Uptodate /Internet/. 2018 /cited 28 nov 2018/. Available from: https://www.uptodate.com/contents/treatment-of-pulmonary-sarcoidosis-initial-therapy-with-glucocorticoids.
7. Fernández Fabrellas E. Epidemiología de la sarcoidosis. Arch Bronconeumol. 2007; 43(2):92-100.
8. Braun JJ, Gentine PG. Sinonasal sarcoidosis: Review and report of fifteen cases. Laryngoscope. 2004; 114(11):1960-3.
9. annuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med. 2007; 357(21):2153-65.
10. Karunakara BP, Maiya PP, Mallikarjuna HB. Childhood sacoidosis presenting as recurrent erythema nodosum. Indian J Pediatr. 2002; 69(9): 829.
11. Zapata González F, Vásquez Ochoa LA, Arroyave Sierra JE, Arredondo Ossa MI, Molina Vélez V, Del Río Cobaleda DY. Sarcoidosis cutánea. CES Med. 2014; 28(2): 293-306.
12. Prystowsky S, Sanchez M. Cutaneous manifestations of sarcoidosis. Uptodate [Internet]. 2019 [cited 2019 Febr 2]. Available from: https://www.uptodate.com/contents/cutaneous-manifestations-of-sarcoidosis?search=sarcoidosis%20cutanea&source=search_result&selectedTitle=1~47&usage_type=default&display_rank=1.
13. Galeano AP, Vecchio E, Calzinari C, Velázquez C, Dilzician V, Guglielmone A, et al. Sarcoidosis cutánea. Rev. argent. dermatol [Internet]. 2013 [cited 2019 febr 2]; 94(4): 22-4. Available from: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-300X2013000400007.
14. Shane E. Diagnostic approach to hypercalcemia. Uptodate [Internet]. 2018 [cited 2019 Febr 1]. Available from: https://www.uptodate.com/contents/diagnostic-approach-to-hypercalcemia?search=hipercalcemia&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1#H3446399644.
15. Baughman RP, Teirstein AS, Judson MA, Rossman MD, Yeager H Jr, Bresnitz EA, et al. Clinical characteristics of patients in a case control study of sarcoidosisl. Am J Respir Crit Care Med. 2001;164(10 Pt 1):1885-9.
16. Villanueva Gimeno MM, Kurnat Y, Vázquez Rodríguez J, Gracia Sánchez MP, Galindo Esteban MC. Síndrome de Löfgren. A propósito de un caso. SEMERGEN. 2009; 35(5):249-51.
17. Mañá J. Diagnóstico y tratamiento de la patología de la sarcoidosis. Barcelona : Servicio de Medicina Interna. Hospital Universitari de Bellvitge. IDIBELL. L’Hospitalet de Llobregat; 2009.
18. Prystowsky S, Sanchez M. Management of cutaneous sarcoidosis. Uptodate [Internet]. 2017 [cited 2019 Enero 30]. Available from: https://www.uptodate.com/contents/management-of-cutaneous-sarcoidosis?search=sarcoidosis%20cutanea&source=search_result&selectedTitle=2~47&usage_type=default&display_rank=2#H324690.
