Un nuevo desafío para los médicos del Paraguay: la nefritis intersticial crónica de comunidades agrícolas (CINAC)
Palabras clave:
CINAC, insuficiencia renal crónica, nefritis intersticial
Resumen
Se presenta revisión narrativa sobre nefritis intersticial crónica de comunidades agrícolas (CINAC, siglas del inglés Chronic Interstitial Nephritis in Agricultural Communities). Se discute la etiología, manifestaciones clínicas, manejo diagnóstico y terapéutico de esta afección.
Citas
1. Orantes Navarro CM, Herrera Valdés R, López MA, Calero DJ, Fuentes de Morales J, Alvarado Ascencio NP, Vela Parada XF, Zelaya Quezada SM, Granados Castro DV, Orellana de Figueroa P. Epidemiological characteristics of chronic kidney disease of non-traditional causes in women of agricultural communities of El Salvador. Clin Nephrol. 2015;83(7 Suppl 1):S24-31. doi: 10.5414/cnp83s024
2. Vervaet BA, Nast CC, Schreurs G, Jayasumana Ch, Herath C, Kojc N, De Broe ME. Chronic interstitial nephritis in agricultural communities: a new perspective on etiology, diagnosis and mechanism. Nephrol Ther. 2021;17S: S45-S50. doi: 10.1016/j.nephro.2020.02.010
3. Wu H, Huang J. Drug-induced nephrotoxicity: Pathogenic mechanisms, biomarkers and prevention strategies. Curr Drug Metab. 2018;19(7):559-67. doi: 10.2174/1389200218666171108154419
4. Perazella MA. Renal vulnerability to drug toxicity. Clin J Am Soc Nephrol. 2009, 4(7): 1275-83. doi: 10.2215/CJN.02050309
5. Karie S, Launay-Vacher V, Deray G, Isnard-Bagnis C. Toxicité rénale des médicaments. Nephrol Ther. 2010; 6(1):58-74. doi: 10.1016/j.nephro.2009.02.006
6. Mostafalou S, Abdollahi M. Pesticides and human chronic diseases: evidences, mechanisms, and perspectives. Toxicol Appl Pharmacol. 2013; 268(2):157-77. doi: 10.1016/j.taap.2013.01.025
7. Mejía R, Quinteros E, López A, Ribó A, Cedillos H, Orantes C, et al. Pesticide-handling practices in agriculture in El Salvador: An example from 42 patient farmers with chronic kidney disease in the Bajo Lempa Region. Occup Dis Environ Med. 2014;2(2):56-70. doi: 10.4236/odem.2014.23007
8. Orantes Navarro CM, Almaguer López M, Alonso Galbán P, Díaz Amaya M, Hernández S, Herrera Valdés R, Silva Aycaguer LC. The chronic kidney disease epidemic in El Salvador: the influence of agrochemicals. Rev Cuba Med Tropical [Internet]. 2020 [citado 2020 Sep 12];72(2):e531. Disponible en: http://revmedtropical.sld.cu/index.php/medtropical/article/view/531/325
9. Vervaet BA, Nast CC, Jayasumana Ch, Schreurs G, Roels F, Herath Ch, et al. Chronic interstitial nephritis in agricultural communities is a toxin-induced proximal tubular nephropathy. Kidney Int. 2020; 97(2):350-69. doi: 10.1016/j.kint.2019.11.009
10. Allison SJ. Toxins linked to chronic interstitial nephritis in agricultural communities. Nat Rev Nephrol. 2020; 16(3):132. doi: 10.1038/s41581-019-0239-z
11. Flores L, Gamarra G, González de Bóveda H, Paredes M. Monitoreo comunitario para la vigilancia de exposición al uso de plaguicidas en Paraguay, Año 2018. Rev. salud publica Parag [Internet]. 2019 [citado 21 Abr. 2022]; 9(1): 9-18. Disponible en: http://scielo.iics.una.py/scielo.php?script=sci_arttext&pid=S2307-33492019000100009&lng=en. https://doi.org/10.18004/rspp.2019.junio.9-18
12. Gamarra MG, Tullo E, Salinas Z, Flores L, Paredes M, González H. et al. Implementación de herramienta tecnológica (TIC) para la vigilancia de factores ambientales y posibles afecciones relacionadas a la exposición por uso de plaguicidas agrícolas en Paraguay. Rev. salud publica Parag [Internet]. 2019 [citado 21 Abr. 2022]; 9(1): 19-32. Disponible en: http://scielo.iics.una.py/scielo.php?script=sci_arttext&pid=S2307-33492019000100019&lng=en. https://doi.org/10.18004/rspp.2019.junio.19-32
13. Cabrera J. WE, Vervaet BA, Scheurs G, Nast CC, Santa-Cruz F, De Broe ME. Chronic interstitial nephritis in agricultural communities: A patient in Paraguay. Kidney Int Rep. 2022;7(5):1131-5. https://doi.org/10.1016/j.ekir.2022.02.019
14. Obrador Vera GT. Enfermedad renal crónica. En: Farreras/Rozman. Medicina interna. 19ª ed. Barcelona: Elsevier; 2020. pp: 836-41. V.I
15. García-Trabanino R, Cerdas M, Madero M, Jakobsson K, Barnoya J, Crowe J, et al. Nefropatía mesoamericana: revisión breve basada en el segundo taller del Consorcio para el estudio de la Epidemia de Nefropatía en Centroamérica y México (CENCAM). Nefrol Latinoam. 2017;14(1):39-45. https://doi.org/10.1016/j.nefrol.2016.11.001
16. Johnson RJ, Wesseling C, Newman LS. Chronic kidney disease of unknown cause in agricultural communities. N Engl J Med. 2019; 380(19):1843-52. doi: 10.1056/NEJMra1813869
17. Siriwardhana EARIE, Perera PAJ, Sivakanesan R, Abeysekara T, Nugegoda DB, Jayaweera JAAS. Dehydration and malaria augment the risk of developing chronic kidney disease in Sri Lanka. Indian J Nephrol. 2015; 25(3):146-51. doi: 10.4103/0971-4065.140712
18. Orantes-Navarro CM, Herrera-Valdés R, Almaguer-López M, López-Marín L, Vela-Parada XF, Hernandez-Cuchillas M, Barba LM. Toward a comprehensive hypothesis of chronic interstitial nephritis in agricultural communities. Adv Chronic Kidney Dis. 2017; 24(2):101-106. doi: 10.1053/j.ackd.2017.01.001
19. Jayasumana C, Orantes C, Herrera R, Almaguer M, Lopez L, Silva LC, Ordunez P, Siribaddana S, Gunatilake S, De Broe ME. Chronic interstitial nephritis in agricultural communities: a worldwide epidemic with social, occupational and environmental determinants. Nephrol Dial Transplant. 2017 Feb 1;32(2):234-241. doi: 10.1093/ndt/gfw346.
20. Wernerson A, Wijkström J, Elinder CG. Update on endemic nephropathies. Curr Opin Nephrol Hypertens. 2014; 23(3):232-8. doi: 10.1097/01.mnh.0000444911.32794.e7
21. Fischer RSB, Vangala Ch, Truong L, Mandayam S, Chavarria D, Granera Llanes OM, et al. Early detection of acute tubulointerstitial nephritis in the genesis of Mesoamerican nephropathy. Kidney Int. 2018; 93(3):681-90. doi: 10.1016/j.kint.2017.09.012
22. Vervaet BA, D'Haese PC, Verhulst A. Environmental toxin-induced acute kidney injury. Clin Kidney J. 2017; 10(6):747-58. doi: 10.1093/ckj/sfx062
23. Rena G, Hardie DG, Pearson ER. The mechanisms of action of metformin. Diabetologia. 2017; 60(9):1577-85. doi: 10.1007/s00125-017-4342-z
24. Lalau JD, Arnouts P, Sharif A, De Broe ME. Metformin and other antidiabetic agents in renal failure patients. Kidney Int. 2015; 87(2):308-22. doi: 10.1038/ki.2014.19
25. De Broe ME, Kajbaf F, Lalau JD. Renoprotective effects of metformin. Nephron. 2018;138(4):261-74. doi: 10.1159/000481951
26. Song A, Zhang Ch, Meng X. Mechanism and application of metformin in kidney diseases: An update. Biomed Pharmacother. 2021; 138:111454. doi: 10.1016/j.biopha.2021.111454
2. Vervaet BA, Nast CC, Schreurs G, Jayasumana Ch, Herath C, Kojc N, De Broe ME. Chronic interstitial nephritis in agricultural communities: a new perspective on etiology, diagnosis and mechanism. Nephrol Ther. 2021;17S: S45-S50. doi: 10.1016/j.nephro.2020.02.010
3. Wu H, Huang J. Drug-induced nephrotoxicity: Pathogenic mechanisms, biomarkers and prevention strategies. Curr Drug Metab. 2018;19(7):559-67. doi: 10.2174/1389200218666171108154419
4. Perazella MA. Renal vulnerability to drug toxicity. Clin J Am Soc Nephrol. 2009, 4(7): 1275-83. doi: 10.2215/CJN.02050309
5. Karie S, Launay-Vacher V, Deray G, Isnard-Bagnis C. Toxicité rénale des médicaments. Nephrol Ther. 2010; 6(1):58-74. doi: 10.1016/j.nephro.2009.02.006
6. Mostafalou S, Abdollahi M. Pesticides and human chronic diseases: evidences, mechanisms, and perspectives. Toxicol Appl Pharmacol. 2013; 268(2):157-77. doi: 10.1016/j.taap.2013.01.025
7. Mejía R, Quinteros E, López A, Ribó A, Cedillos H, Orantes C, et al. Pesticide-handling practices in agriculture in El Salvador: An example from 42 patient farmers with chronic kidney disease in the Bajo Lempa Region. Occup Dis Environ Med. 2014;2(2):56-70. doi: 10.4236/odem.2014.23007
8. Orantes Navarro CM, Almaguer López M, Alonso Galbán P, Díaz Amaya M, Hernández S, Herrera Valdés R, Silva Aycaguer LC. The chronic kidney disease epidemic in El Salvador: the influence of agrochemicals. Rev Cuba Med Tropical [Internet]. 2020 [citado 2020 Sep 12];72(2):e531. Disponible en: http://revmedtropical.sld.cu/index.php/medtropical/article/view/531/325
9. Vervaet BA, Nast CC, Jayasumana Ch, Schreurs G, Roels F, Herath Ch, et al. Chronic interstitial nephritis in agricultural communities is a toxin-induced proximal tubular nephropathy. Kidney Int. 2020; 97(2):350-69. doi: 10.1016/j.kint.2019.11.009
10. Allison SJ. Toxins linked to chronic interstitial nephritis in agricultural communities. Nat Rev Nephrol. 2020; 16(3):132. doi: 10.1038/s41581-019-0239-z
11. Flores L, Gamarra G, González de Bóveda H, Paredes M. Monitoreo comunitario para la vigilancia de exposición al uso de plaguicidas en Paraguay, Año 2018. Rev. salud publica Parag [Internet]. 2019 [citado 21 Abr. 2022]; 9(1): 9-18. Disponible en: http://scielo.iics.una.py/scielo.php?script=sci_arttext&pid=S2307-33492019000100009&lng=en. https://doi.org/10.18004/rspp.2019.junio.9-18
12. Gamarra MG, Tullo E, Salinas Z, Flores L, Paredes M, González H. et al. Implementación de herramienta tecnológica (TIC) para la vigilancia de factores ambientales y posibles afecciones relacionadas a la exposición por uso de plaguicidas agrícolas en Paraguay. Rev. salud publica Parag [Internet]. 2019 [citado 21 Abr. 2022]; 9(1): 19-32. Disponible en: http://scielo.iics.una.py/scielo.php?script=sci_arttext&pid=S2307-33492019000100019&lng=en. https://doi.org/10.18004/rspp.2019.junio.19-32
13. Cabrera J. WE, Vervaet BA, Scheurs G, Nast CC, Santa-Cruz F, De Broe ME. Chronic interstitial nephritis in agricultural communities: A patient in Paraguay. Kidney Int Rep. 2022;7(5):1131-5. https://doi.org/10.1016/j.ekir.2022.02.019
14. Obrador Vera GT. Enfermedad renal crónica. En: Farreras/Rozman. Medicina interna. 19ª ed. Barcelona: Elsevier; 2020. pp: 836-41. V.I
15. García-Trabanino R, Cerdas M, Madero M, Jakobsson K, Barnoya J, Crowe J, et al. Nefropatía mesoamericana: revisión breve basada en el segundo taller del Consorcio para el estudio de la Epidemia de Nefropatía en Centroamérica y México (CENCAM). Nefrol Latinoam. 2017;14(1):39-45. https://doi.org/10.1016/j.nefrol.2016.11.001
16. Johnson RJ, Wesseling C, Newman LS. Chronic kidney disease of unknown cause in agricultural communities. N Engl J Med. 2019; 380(19):1843-52. doi: 10.1056/NEJMra1813869
17. Siriwardhana EARIE, Perera PAJ, Sivakanesan R, Abeysekara T, Nugegoda DB, Jayaweera JAAS. Dehydration and malaria augment the risk of developing chronic kidney disease in Sri Lanka. Indian J Nephrol. 2015; 25(3):146-51. doi: 10.4103/0971-4065.140712
18. Orantes-Navarro CM, Herrera-Valdés R, Almaguer-López M, López-Marín L, Vela-Parada XF, Hernandez-Cuchillas M, Barba LM. Toward a comprehensive hypothesis of chronic interstitial nephritis in agricultural communities. Adv Chronic Kidney Dis. 2017; 24(2):101-106. doi: 10.1053/j.ackd.2017.01.001
19. Jayasumana C, Orantes C, Herrera R, Almaguer M, Lopez L, Silva LC, Ordunez P, Siribaddana S, Gunatilake S, De Broe ME. Chronic interstitial nephritis in agricultural communities: a worldwide epidemic with social, occupational and environmental determinants. Nephrol Dial Transplant. 2017 Feb 1;32(2):234-241. doi: 10.1093/ndt/gfw346.
20. Wernerson A, Wijkström J, Elinder CG. Update on endemic nephropathies. Curr Opin Nephrol Hypertens. 2014; 23(3):232-8. doi: 10.1097/01.mnh.0000444911.32794.e7
21. Fischer RSB, Vangala Ch, Truong L, Mandayam S, Chavarria D, Granera Llanes OM, et al. Early detection of acute tubulointerstitial nephritis in the genesis of Mesoamerican nephropathy. Kidney Int. 2018; 93(3):681-90. doi: 10.1016/j.kint.2017.09.012
22. Vervaet BA, D'Haese PC, Verhulst A. Environmental toxin-induced acute kidney injury. Clin Kidney J. 2017; 10(6):747-58. doi: 10.1093/ckj/sfx062
23. Rena G, Hardie DG, Pearson ER. The mechanisms of action of metformin. Diabetologia. 2017; 60(9):1577-85. doi: 10.1007/s00125-017-4342-z
24. Lalau JD, Arnouts P, Sharif A, De Broe ME. Metformin and other antidiabetic agents in renal failure patients. Kidney Int. 2015; 87(2):308-22. doi: 10.1038/ki.2014.19
25. De Broe ME, Kajbaf F, Lalau JD. Renoprotective effects of metformin. Nephron. 2018;138(4):261-74. doi: 10.1159/000481951
26. Song A, Zhang Ch, Meng X. Mechanism and application of metformin in kidney diseases: An update. Biomed Pharmacother. 2021; 138:111454. doi: 10.1016/j.biopha.2021.111454
